NuCLEANase^®

Enzymatic removal of DNA, for regulatory compliance and process efficiency improvements of fermentative processes 

NuCLEANase^® is an endonuclease, which can be used for the enzymatic removal of nucleic acids in a large variety of bioprocesses.  A frequent application is the reduction of residual NuCLEANase^® DNA for regulatory compliance of fermentation processes.  

NuCLEANase^® can contribute to a more efficient production process of microbial derived products. It reduces the nucleic acid induced viscosity, which makes the recovery process easier.  

As NuCLEANase^® is beneficial for a wide range of biotech applications it comes as a food- and tech-grade formulation. The food-grade is halal/kosher certified and listed on the FDAs GRAS Inventory List.

After submitting a GRAS notification for NuCLEANase^® (GRN No.1146) to the US FDA, c-LEcta has received a "No questions letter” from the authority, which is publicly available within the GRAS Inventory List. The GRAS Notification designates that the usage of NuCLEANase^® in food applications is considered safe under the conditions of its intended use.  

For which Application Field do you need NuCLEANase^®?

In fermentative derived products, NuCLEANase^® can be used for the removal of residual DNA from genetically modified production hosts for regulatory compliance.

In phage manufacturing processes NuCLEANase^® is used to specifically remove nucleic acids from cell lysates to reduce the viscosity and aggregate formation and hence facilitates the purification of the phages.

In fermentation processes, NuCLEANase^® can be used to reduce the nucleic acid induced viscosity in fermentation broths, enabling a significantly more efficient process.

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