About NuCLEANase^®

NuCLEANase^® is a food-grade endonuclease, which can be used for the removal of nucleic acids in a large variety of biotech processes.  

NuCLEANase^® is a recombinant Serratia marcescens endonuclease produced in Bacillus sp. The enzyme cleaves all forms of DNA/RNA by catalyzing the hydrolysis of the phosphodiester bonds between nucleotides, leaving short fragments with a length of 2 to 5 base pairs.

Depending on your application NuCLEANase^® is available as a tech-grade or food-grade, liquid formulation. The food grade product is considered as a processing aid and comes with halal/kosher certification. Further the product is listed on the FDAs GRAS Inventory List, which designates the safety of the product under the conditions of its intended use.

Applications

NuCLEANase^® is intended for the hydrolysis of nucleic acids during manufacturing of microbial-derived products and is often used for the following applications:

• Removal of residual host DNA in food and feed enzymes, ensuring compliance with the relevant regulatory guidelines

• Viscosity reduction of the fermentation broth by nucleic acids digestion to improve the efficacy of the recovery

• Bacteriophage production

Benefits

Highly
cost-efficient

Highly active - cleaves all forms
of DNA and RNA to 2-5 oligonucleotides

Free of antibiotics &
animal derived raw materials

For which Application Field do you need NuCLEANase^®?

In fermentative derived products, NuCLEANase^® can be used for the removal of residual DNA from genetically modified production hosts for regulatory compliance.

In phage manufacturing processes NuCLEANase^® is used to specifically remove nucleic acids from cell lysates to reduce the viscosity and aggregate formation and hence facilitates the purification of the phages.

In fermentation processes, NuCLEANase^® can be used to reduce the nucleic acid induced viscosity in fermentation broths, enabling a significantly more efficient process.

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