About NuCLEANase®

NuCLEANase® is recombinantly expressed endonuclease from Serratia marcescens. The production organism is a QPS/GRAS strain from Bacillus sp. NuCLEANase® catalyzes the hydrolysis of phosphodiester bonds between nucleotides, leaving short fragments with a length of 2 to 5 bases and a 5’-monophosphate end. NuCLEANase® cleaves all forms of DNA/RNA (single-stranded, double-stranded, linear, and circular).

In the food or feed sector, the applications are manifold. NuCLEANase® enables the efficient removal of residual host DNA in food and feed enzymes as well as other fermentation products, thus ensuring their compliance with the relevant regulatory guidelines. Likewise, NuCLEANase® can improve process efficiency by reducing the viscosity of the fermentation solution.

As a leading supplier of enzyme technologies, c-LEcta is offering a nuclease for the first time in industrial quantities at affordable prices. Depending on the application and the end product, NuCLEANase® is available in tech-grade or food-grade quality; with the latter being halal/kosher-certified. The production host is a QPS/GRAS strain and no antibiotics or animal-derived materials are used in the manufacturing process.






Highly active - cleaves all forms
of DNA and RNA to 2-5 oligonucleotides

c-LEcta_ICON_free of antibiotics

Free of antibiotics &
animal derived raw materials


Wide range of
operating conditions


Full technical support
by experts


Kosher &

For which application field do you need NuCLEANase®?

Fermentation products

In food fermentation products, NuCLEANase® ensures efficient removal of residual host DNA for regulatory compliance and viscosity reduction.

Phage production

NuCLEANase® lowers viscosity and hence facilitates the purification of phages used as natural preservatives or anti-infectives.

Biofilm control

NuCLEANase®, as part of a multi-component cleaning formulation can enable efficient elimination of stubborn biofilms in domestic, industrial, or medical settings.

Order & test NuCLEANase® now!

Whether it is in small quantities via our online shop or in large quantities – we are happy that you are considering our high-performance nuclease for industrial applications. So no matter if you already know what you need or if you want to discuss NuCLEANase® with one of our experts – we are here to support you.

For smaller quantities

If you need NuCLEANase® in smaller quantities  for further testing and small piloting, you can ordner it directly in our online shop.

For larger quantities

Please get in contact to inquire about pricing in larger quantities. Our NuCLEANase® expert team looking forward to support you.

Get in touch with our NuCLEANase® 
expert team!

We are looking forward to support you with your question. It would our pleasure to discuss NuCLEANase® and how it can be used for your production processes.

Need support? Contact me!

Simon Ulm

Simon Ulm